1.
Warm Up: Campus spirit
in the 70s meant something different than today
2.
Mariana and
Nancy: Adult Changes in Thought (ACT)
a. What does “ACT”
really mean here?
i.
Long term study, including post mortem study of brain tissue
ii.
Here: short term, survey based review
b. Overview
i.
Comparison of physical activity and cognition
1. What is our
population’s exercise related activities (mode, frequency, intensity, duration)
a. Many types; dichotomized
into “physical” and “motor”
i.
Physical: repetitive
ii.
Motor: high neuromuscular demand
2. How PA relates
to CASI (cognitive abilities screening instrument)
ii.
Exploratory design based on a lot of descriptive data
1. E.g. Do those
with >1 exercise have higher CASI scores
2. Overall: what characteristics
of exercise are related to higher CASI
iii.
Approach: model development through correlation analysis
1. Possible questions
can range in complexity, e.g. determining the simultaneous effect of many
factors on the outcome is very complicated
2. A simpler and still
FINER question tests the dichotomy between physical and motor categories of
exercise
c. Seeking an
approach that provides a recommendation for what kind of exercise to do
i.
Each subject has an array of characteristics (mode, etc.)
1. Each characteristic
is a variable with CI’s and P values
2. Analysis
controls for some characteristics (frequency, intensity) in order to evaluate
the others
ii.
Subjects: 1100 – 1300
1. Allows for a
variety of characteristics
2. Split on
motor/physical and test this theory (this dichotomy) – this keeps the analysis
cleaner
iii.
Categorization of exercise
1. Physical:
repetition vs. Motor: ACM “skill related elements”, power and reaction time
2. This is different
from “aerobic” vs “nonaerobic” later in the document; be consistent
iv.
What is the research question:
1. Test a
hypothesis
a. Does the
distinction between physician vs motor have meaning? Cofounders don’t matter.
b. If asking why,
then confounders matter a lot.
2. Describe many
variables
3. Case control:
which were the best outcomes – but this is for studies where collecting the
data is difficult or few for the cases and the controls are plentiful
d. Review of the
survey
i.
To what degree does the survey identify the dichotomy of physical
vs motor
ii.
The CASI provides many outcomes and the data on exercise provides
many variables: need a science theory to help specify a valuable relationship
1. Initial plan:
classify degree of cognitive impairment, but there are no cutoff scores that
matter
2. Consider
splitting at median CASI score, resulting in a dichotomous outcome
3. Consider
splitting exercise into “one kind” vs “variety of exercises” – is this FINER?
4. Consider
creating an index of variability of exercise use
e. Table 5
i.
Stay away from many categories
3.
4/30: Open for suggestions
a. Future topics
TBD
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