Monday, December 10, 2012

Clinical Research Oriented Workshop (CROW) Meeting: Dec 6, 2012

Present: Kairn Kelley, Rodger Kessler, Ben Littenberg, Prema Menon, Connie van Eeghen

1.                  Start Up:  Inter-rater Reliability article update. Box and whisker plot is successful to show differences in inter-rater reliability over time (over the study period and over the ordinal placement of the subject on each day of testing)

2.                  Presentation: Kairn: F31 grant application for career development of pre-doctoral fellows: stipend, research, and tuition for 2-5 years. Goal: to structure and fund dissertation
a.       Domain (as written in May):
                                                  i.      “What role could dichotic listening testing play in the assessment of children with ADHD?”
                                                ii.      The definition of ADHD includes two subgroups (inattention and hyperactive)
b.      Plan (from May)
                                                  i.      Lit review
                                                ii.      Select tests [deliverable paper on available tests]
                                              iii.      Subjects (define population)
                                              iv.      Test each subject twice
                                                v.      Analyze
c.       Aims (from May):
                                                  i.      ADHD-PI score differently than ADHD-C
                                                ii.      ADHD score differently than normal
d.      Lit Review Thus far reveals some opportunities:
                                                  i.       need for basic epidemiologic studies of APD test performance
                                                ii.      There is an association between the two diagnoses: ADHD (diagnosed by set of symptoms) vs. APD (auditory processing disorder, diagnosed by a set of test results)
e.       Discussion:
                                                  i.      Consider an epidemiologic question: what is the distribution in a population of children for the prevalence of APD and ADHD.
1.      Aim 1: mean and std dev for dichotic test
2.      Aim 2: correlation between APD and ADHD
3.      Aim 3: percent overlap
4.      Aim 4: how much does one test identify the other result
5.      Aim 5: does the remedy for ADHD have an effect on APD
                                                ii.      Consider a study in an “enriched population” of children who are likely to have ADHD and are likely to have APD: “Is dichotic testing a good test of ADHD?”
                                              iii.      Measure stability of scores as a phase 1 study:
1.      How stable is the test?
2.      Is APD a trait or a state?
3.      Is the measure stable?
4.      Is the score associated with ADHD?
5.      Is instability in the score associated with ADHD?
6.      What does the normal population look like?”
7.      How long a period of time should elapse to retest in a child?
8.      Should the study include a combination of words that are presented to both ears (cat/dog and also dog/cat)?
9.      Does the data that were collected in the pre-test show that the first 25 word combinations result in the same scores as the last 25 word combinations?
10.  Test in the “normal” population, ADHD population, and APD population to test the difference. 
f.       Call the project officer about details related to the application, e.g. does the sponsor need to have a current R01 grant?

3.                  Next Workshop Meeting(s): Thursday, 2:00 p.m. – 3:30 p.m., at Given Courtyard Level 4. 
a.       Dec 13: Prema: draft grant application. (No Ben)
b.      Dec 20: Winter break – next meeting is on January 3, 2:00 – 3:30.    
c.       Future agenda to consider:
                                                  i.      Ben: budgeting exercise for grant applications; NHANES – lower female mortality for women taking birth control medications
                                                ii.      Rodger: Mixed methods article; article on Behavior’s Influence on Medical Conditions (unpublished); drug company funding.  Also: discuss design for PCBH clinical and cost research.  Also: Prezi demo. 
                                              iii.      Amanda: presentation and interpretation of data in articles
                                              iv.      Christina Cruz, 3rd year FM resident with questionnaire for mild serotonin withdrawal syndrome on 12/6 or 12/13

Recorder: Connie van Eeghen and Kairn Kelley

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