Wednesday, January 10, 2018

Clinical Research Oriented Workshop (CROW) Meeting: January 4, 2018



Present:   Levi Bonnell, Marianne Burke, Nancy Gell, Kairn Kelley, Connie van Eeghen

Start Up: Generalized Linear Models: using a link function to model data linearly that is not normally distributed: what Kairn and Levi have to learn based on a reviewer’s recommendation in response to a manuscript

1.                   IBH-PC Temporal Control Study – Connie’s upcoming UVM Reach Grant application draft
a.       Description
                                                   i.      Clarify timeline
                                                 ii.      The innovation is the new method
                                               iii.      Clarify methods, what’s on the 3rd page comes too late – front load this and the value (below)
b.       1st page
                                                   i.      Why should I care – what’s the value
1.       We spend lots of money on control arms
2.       This could explode the way we do control arms
3.       Questions – get excited about these
a.       Can we create a comparator
b.       Can we detect similarities
c.       Can we detect differences
4.       Method of forming a control group has strengths: a random selection of subjects to create many possible control arms, one of which is randomly selected; strengthens the conclusions of any research project that uses this method: scale and randomness
                                                 ii.      Value and challenge
1.       Lower cost and greater impact for UVM researchers to use; increased capability and opportunities to share and network
2.       PCORI is the opportunity; this is a chance to take advantage of it
3.       Overcomes the challenges of lack of interoperability of EHRs through better use of data warehouses
                                               iii.      Take emphasis off the constraints of the current study; focus on the opportunity for future studies
c.       Re-read for language and acronyms
                                                   i.      Constellations of practices
d.       Researcher Goals:
                                                   i.      This provides important pilot data to be PI in a bigger grant
e.       Explain Part 2 earlier
                                                   i.      Also include in Research Goals: now we can answer these questions

2.                   Next Workshop Meeting(s): Thursdays, 11:30 p.m. – 12:45 p.m., at Given Courtyard South Level 4.
a.       Jan 11: Justine Dee’s abstract
b.       Jan 18: TBD
c.       Future topics:
a.       Juvena: protocol development
b.       LaMantia: predictors of successful R01 applications: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155060

Recorder: Connie van Eeghen

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