CROW 9/26

Ben Littenberg, Mariana Wingood, Justine Dee, Levi, Bonnell, Juvena Hitt, CvE

1.       Poster presentations

a.        Choose 3-4 key items from each trial

b.       Match to the PRECIS diagram

c.        Add conclusions at the bottom

d.       Left side: methods, goal, objectives...

e.        Why NAPCRG

                                                   i.      PC studies

                                                 ii.      Pragmatic

                                               iii.      Complex

                                               iv.      Here’s what we learned

1.       Generalizable (externally valid) vs internally valid – essentially true of all science

a.        Pragmatic trials are different by degree

b.       Are they more complex – i.e. unpredictable

c.        The volume of challenges

                                                                                                                           i.      Data sampling frame / recruitment

                                                                                                                         ii.      Data collection

                                                                                                                       iii.      Intervention

d.       Good research is hard; what makes pragmatic trials hard magnifies these issues: high levels of external/internal validity with complex interventions on complex population.  Complexity exists in all science; pragmatic trials bite them off all at once, rather than trying them one at a time. We are understanding the world of people, necessarily complex.

2.       Flexibility

3.       Team work

2.       Content

a.        Too dense

                                                   i.      Simplify to “this is the challenge” and “this is how addressed”

b.       Implementation issue: changed to empower sites to modify the intervention

c.        Outcomes: challenge in the clinic to collect outcomes data; sites empowered (PREPARE)

3.       Three worlds of CJ Peek – to be distributed

4.       Next week: open

a.        Following week: Jen’s discussion on Oct 10

It look like the paper Connie was referencing is actually a book chapter
https://link.springer.com/chapter/10.1007/978-0-387-76894-6_3

I also found some lecture slides given by CJ Peek on the topic
http://www.cbhc.org/news/wp-content/uploads/2010/07/Session-1003.pdf