Clinical Research Oriented Workshop (CROW) Meeting: November 12, 2020

 

Present:   Levi Bonnell, Justine Dee, Juvena Hitt, Emily Houston, Ben Littenberg, Adam Sprouse-Blum, Connie van Eeghen, (7)

1.                   Warm Up: (tech issues – on radio silence at start up)

2.                   Adam: re-application to continue loan repayment program

a.       Little known about reviewers; might be admin only

                                                   i.      Success rate for 1^st for app is 50%

                                                 ii.      Success rate for reapplication is 70%

b.       Composition/organization

                                                   i.      Define the medical terms, e.g. Gastroparesis

                                                 ii.      State the general “need to fill this gap” up front, not at the end

                                               iii.      Use images/illustrations to support complex idea; duplication between documents is OK and even helpful

c.       Design

                                                   i.      Explain why excluding pregnant subjects

                                                 ii.      Consent methods: all with a face – in person or Zoom – this is a good method, but phone is faster and sometimes helpful.  REDCap consent is OK too.

                                               iii.      Include participant incentive as part of the consent procedure

                                               iv.      Evaluate figures for their content and value

                                                 v.      Describe plan to develop a bio-bank of samples

                                               vi.      Sample selection (which sample to analyze than more than one sample provided) depends on the logic model: which is the predictor, the microbiome or the migraine? Build the design around the model.

                                              vii.      Consider how other sources of data will be used in the design, e.g. the role of the food diary

                                            viii.      Make sure that the analytic method fits the data, using standard, accepted language

                                                ix.      Diagrams, if not intuitive, should be explained

1.       Use diagrams to tell a story, e.g. before/after sample analysis

2.       Define the panel – who is included

3.                   Next week:  Systematic Review with Emily or review of NIH website?