Adverse drug event trigger tool: a practical methodology for measuring medication related harm
The authors describe a checklist for finding adverse drug events by manual review of hospital charts. Triggers are things like use of an "antidote" (naloxone after narcotic overdose), laboratory effects of ADEs (high PTT), and orders to stop drugs abruptly.. Then a judgment is made if it was due to a medication. About 1/4 of triggers are classified as ADEs. In 2,837 discharges from 86 hospitals, they found 720 ADEs for 2.68/1000 doses. 25% of charts had an ADE.
I found the article interesting because it standardizes an area of Quality Improvement work that could otherwise be very prone to so much variation and noise as to make the results useless.
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