New Funding Opportunity for Early Career Investigators

From: CVRI-VT <CVRI-VT@med.uvm.edu>
Sent: Saturday, January 18, 2020 8:39 AM
Subject: NEW Funding Opportunity for Early Career Investigators in Cardiovascular Research_ Apps due Feb 14

Subject: NEW Funding Opportunity for Early Career Investigators in Cardiovascular Research

Please distribute throughout your department and lab group!

The Early Career Advisory Committee of the CVRI is pleased to announce a unique funding opportunity for Early Career investigators who are developing new skills and/or who are seeking a novel research experience aimed at developing a career in cardiovascular research.  

Eligibility: 

·         Early career investigators at UVM who are working with a UVM mentor or an external (non-UVM) mentor

·         Early career investigators at external institutions who will be working with a mentor at UVM

·         For the purpose of this funding, early career investigators are considered to be:

o   Undergraduate, Masters, and PhD students

o   2^nd, 3^rd, and 4^th year medical students

o   Postdoctoral fellows

o   Residents and clinical fellows

o   Faculty and Staff within 5 years of their first appointment

Funding:  Applications requesting up to $10,000 will be considered. 

For more details and application instructions, please see the attached document. 

The complete application is due by February 14, 2020.

Please contact CVRI-VT@med.uvm.edu if you have any questions. 

Sponsored by the CVRI Early Career Advisory Committee

Cardiovascular Research Institute of Vermont. 

 

 

New paper for Adam Sprous-Blum

Congratulations to Adam Sprouse-Blum, MD, Assistant Professor of Neurology and doctoral candidate in CTS. He and colleagues just published their work on familial migraine.

Headache. 2020 Jan 22. doi: 10.1111/head.13741. [Epub ahead of print]

Familial "Diplegic" Migraine - Description of a Family With a Novel CACNA1A Mutation.

Sprouse Blum AS¹, Couperus CJ², Rosen BJ², Haskin-Leahy LF³, Shapiro RE¹.

OBJECTIVE:

To characterize phenotypes of a novel CACNA1A mutation causing familial hemiplegic migraine type 1.

BACKGROUND:

Familial hemiplegic migraine is a rare monogenic form of migraine associated with attacks of fully reversible unilateral motor weakness. We now report a novel CACNA1A gene mutation associated with fully reversible bilateral motor weakness (diplegia).

METHODS:

The proband underwent genotyping which identified a novel CACNA1A missense mutation (c.622 [isoform 1] G > A [p.Gly208Arg]). To characterize phenotypes associated with this novel mutation, the proband and 8 of her similarly affected family members underwent a semi-structured interview.

RESULTS:

All 9 subjects who were interviewed met ICHD-3 phenotypic diagnostic criteria for FHM, including reporting attacks with reversible unilateral motor weakness. Additionally, 7 of 9 subjects reported attacks including reversible motor weakness affecting both sides of the body simultaneously.

CONCLUSIONS:

We describe a novel CACNA1A mutation associated with migraine attacks including reversible diplegia.

© 2020 American Headache Society.    DOI: 10.1111/head.13741

Fwd: Webinar Announcement: Final 2018 Mortality Data Release with a Special Highlight on Maternal Mortality

January 24, 2020

Webinar Announcement: Final 2018 Mortality Data Release with a Special Highlight on Maternal Mortality The National Center for Health Statistics (NCHS) will release the Final 2018 Mortality File and accompanying reports on Thursday, January 30, 2020. In addition to reports highlighting life expectancy and drug overdose, NCHS will release new reports on maternal mortality measurement in the United States, along with detailed data files for researchers. With the release of these data and reports, NCHS is resuming publication of an official Maternal Mortality Rate for the first time since 2007. Join NCHS for a webinar, open to the public, on Thursday, January 30th, at 2:30pm EST, to learn more about the final mortality data release, maternal mortality data, and the new accompanying reports. NCHS will provide detailed information on reporting of maternal mortality statistics, how reporting has changed as states have added a pregnancy checkbox on their death certificates, changing in coding procedures, and the release of the first official national Maternal Mortality Rate since 2007. Webinar Details Thursday, January 30th, at 2:30-3:30 pm EST Participants can join the Skype meeting via the free Skype Meeting App at: https://webconf.cdc.gov/cdclgmeeting1/WBCGJ9CY For the full experience (i.e. audio, video, and chat), attendance through the Skype Meeting App is recommended. However, participants may also dial-in to the audio conference line at (855) 348-8390, Access Code: 609455 It is recommended that those wishing to attend via Skype should test their systems prior to the meeting to ensure access. Help for Skype can be found at: https://support.office.com/en-us/skype-for-business. Live captioning will also be setup for this event. A URL for real-time closed captioning is forthcoming. For the latest information, please see webinar details at: https://www.cdc.gov/nchs/events/webinar-maternal-mortality.htm

National Center for Health Statistics 3311 Toledo Rd   Hyattsville, MD 20782   Centers for Disease Control and Prevention 1600 Clifton Rd   Atlanta, GA 30329   1-800-CDC-INFO (800-232-4636)   TTY: 888-232-6348 Questions or Problems

Clinical Research Oriented Workshop (CROW) Meeting: Jan 23, 2020

Present:   Levi Bonnell, Marianne Burke, Justine Dee, Nancy Gell, Juvena Hitt, Jen Oshita, Gail Rose, Liliane Savard, Connie van Eeghen, Adam Sprouse-Blum, Marian Wingood

1.                   Warm Up: Happy new year

2.                   Review of Connie’s Pragmatic Trial manuscript 

a.       What makes this a methods paper: Example Annals methods paper title: practice approach to qualitative research but not a systematic inquiry; more of a how to

                                                   i.      Not a qualitative research project, but relating the experience of doing a pragmatic study with credentials of writers

b.       This is not about a solution; don’t go into your study thinking your protocol is finished (punch line).  You will be creating new solutions; embrace it.  Relax and pay attention: what’s the research question and how do you answer it without creating bias

c.       Title: approach to... recursive approach to... meta strategies... Problems and experiences in two pragmatic trials (no); an approach to unanticipated problems in pragmatic studies

d.       Outline

                                                   i.      Pragmatic trials have challenges that are not easily anticipated in the protocol (don’t compare to RCTs)

                                                 ii.      What do you do when faced with something not in the protocol, here’s a list of 5 items and 1 sentence on how we responded to each

                                               iii.      Largely successful; what do they have in common

1.       You can’t plan everything ahead of time – improvise and document

2.       Rules: you can change the protocol but any change made does not impair internal/external validity

3.       There are situations where they can’t be fixed and the study fails (the data don’t answer the question)

a.       Many situations where you can fix and succeed (data answers the question without loss of internal/external validity)

b.       Must be honest with stakeholders about modifications to operations that differ from original protocol and why and why it’s not a threat to validity

4.       Bottom line: defending research question is more important than defending the protocol

e.       Lit review

                                                   i.      We identified the problem (describe), also found in (lit sources).  Other problems (more lit sources)

                                                 ii.      Take out everything else; keep this short

f.        PREPARE team

                                                   i.      Ask PI how he does it – a parallel statement to what Ben expressed this meeting: the system for surveillance, response, documenting, and reporting these challenges

g.       Framework

                                                   i.      Don’t talk about what is in the literature; talk about what isn’t – in spite of our best efforts to anticipate everything, we were bombarded with unanticipated problems (volcano – still in project; plus the earthquake, plus the work stoppage...)

h.       Co-authors

                                                   i.      Not reviewing the literature on complexity or reviewing all the problems

                                                 ii.      Once there are problems with suggested solutions, they are no longer complex – there’s a solution

                                               iii.      All the ones you can’t anticipate are fundamentally complex: can’t anticipate all the interactions; must make judgment calls based on protecting the research question and managing: identifying, deciding, documenting, reporting (four boxes)

                                               iv.      Liliane’s process: describe the options and ask for feedback and additional ideas

1.       E.g. how to use the lit review

i.         Other ideas: an article on “pragmatic trials are not pragmatic (as in easy to fit into the clinical practice)”

j.         1/30: TBD

                                                   i.      Future: Marianne Burke on depositing original data in a repository 

Recorded by CvE

New funding for Abby Crocker

Congratulations to Abby Crocker, PhD, Assistant Professor of Mathematics and Statistics. She is part of a UVM team that just got awarded $100,000 to work with the Vermont Department of Corrections to build the state’s capacity for data and research for justice-related issues.

https://www.uvm.edu/cas/news/uvm-scholars-provide-key-research-support-policy-solutions-vermont-prisons

Fwd: FW: CVRI_NEW funding opportunity for early career investigators in cardiovascular research

 

Subject line:  NEW funding opportunity for early career investigators in cardiovascular research

 

Through an endowment established by Martin Bloomfield, MD '60, the Cardiovascular Research Institute of Vermont (CVRI) at UVM is excited to announce a unique funding opportunity for Early Career faculty members who are developing research programs related to cardiovascular diseases.  

 

Eligibility:  Faculty members from any UVM college who are in the initial 5 years of their first faculty appointment (assistant professor).

 

Funding and duration:  $45,000 in funding for each of 2 consecutive academic years, with a possibility of funding for a 3^rd year. 

 

For more details and application instructions, please see the attached documents. 

A letter of intent is required by March 1^st.  The complete application is due by April 15^th. 

 

Please contact CVRI-VT@med.uvm.edu if you have any questions. 

 

 

Fwd: FW: NEW Funding Opportunity for Early Career Investigators in Cardiovascular Research_ Apps due Feb 14

Subject: NEW Funding Opportunity for Early Career Investigators in Cardiovascular Research

Please distribute throughout your department and lab group!

 

The Early Career Advisory Committee of the CVRI is pleased to announce a unique funding opportunity for Early Career investigators who are developing new skills and/or who are seeking a novel research experience aimed at developing a career in cardiovascular research.  

 

Eligibility: 

·         Early career investigators at UVM who are working with a UVM mentor or an external (non-UVM) mentor

·         Early career investigators at external institutions who will be working with a mentor at UVM

·         For the purpose of this funding, early career investigators are considered to be:

o   Undergraduate, Masters, and PhD students

o   2^nd, 3^rd, and 4^th year medical students

o   Postdoctoral fellows

o   Residents and clinical fellows

o   Faculty and Staff within 5 years of their first appointment

 

Funding:  Applications requesting up to $10,000 will be considered. 

 

For more details and application instructions, please see the attached document. 

The complete application is due by February 14, 2020.

 

Please contact CVRI-VT@med.uvm.edu if you have any questions. 

 

Sponsored by the CVRI Early Career Advisory Committee

Cardiovascular Research Institute of Vermont.